|
rs110419
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models.
|
31830377 |
2020 |
|
rs10840002
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The present study aimed to evaluate the impact of the new TSPO ligands on mitochondrial dysfunction in a cellular model of AD-related tauopathy (human neuroblastoma cells SH-SY5Y stably overexpressing the P301L-mutant Tau) presenting mitochondrial impairments, including a decreased ATP synthesis and mitochondrial membrane potential, as well as a decrease in pregnenolone synthesis compared to control cells.
|
31536662 |
2020 |
|
rs204938
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In contrast, the rs204938 polymorphism showed a positive association with NB susceptibility in allele genetic models.
|
31830377 |
2020 |
|
rs4758051
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model.
|
31830377 |
2020 |
|
rs2168101
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models.
|
31830377 |
2020 |
|
rs11247957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs2273267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further independent case-control studies with functional analysis are needed to verify the role of NRAS gene rs2273267 A>T polymorphism in the risk of neuroblastoma.
|
31759987 |
2020 |
|
rs34787247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, our finding indicated that LIN28A SNPs, especially rs34787247 G>A, may increase neuroblastoma risk.
|
31747721 |
2020 |
|
rs3811463
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs3811464
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we evaluated the correlation of four potentially functional LIN28A SNPs (rs3811464 G>A, rs3811463 T>C, rs34787247 G>A, and rs11247957 G>A) and neuroblastoma susceptibility in 505 neuroblastoma patients and 1070 controls from four independent hospitals in China.
|
31747721 |
2020 |
|
rs113994087
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combined treatment with alectinib and vorinostat might be a novel therapeutic option for NB harboring the ALK R1275Q mutation.
|
31262882 |
2019 |
|
rs113994087
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To study the contribution of ALK mutations in NB initiation and progression, we reprogrammed fibroblasts from two related NB patients carrying germline mutations in ALK (R1275Q) using non-integrating Sendai virus.
|
30605844 |
2019 |
|
rs281864719
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Altogether, we report for the first time that the expression of the human ALK-F1174L mutation in NCCs during embryonic development profoundly disturbs early sympathetic progenitor differentiation, in addition to increasing their proliferation, both mechanisms being potential crucial events in NB oncogenesis.
|
31058082 |
2019 |
|
rs281864719
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, lethal neuroblastoma</span> frequently developed in mice co-expressing ALK F1174L and MYCN, even in a genetic background where MYCN alone does not cause overt tumors.
|
31218818 |
2019 |
|
rs863225281
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Altogether, we report for the first time that the expression of the human ALK-F1174L mutation in NCCs during embryonic development profoundly disturbs early sympathetic progenitor differentiation, in addition to increasing their proliferation, both mechanisms being potential crucial events in NB oncogenesis.
|
31058082 |
2019 |
|
rs863225281
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, lethal neuroblastoma</span> frequently developed in mice co-expressing ALK F1174L and MYCN, even in a genetic background where MYCN alone does not cause overt tumors.
|
31218818 |
2019 |
|
rs1386984902
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we aimed to characterize the link between ER stress and bioenergetics defects under normal condition (human SH-SY5Y neuroblastoma cells: control cells) or under pathological AD condition [SH-SY5Y cells overexpressing either the human amyloid precursor protein (APP) or mutant tau (P301L)].
|
30683981 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Overall, we confirmed that miR-34b/c rs4938723 and TP53 Arg72Pro conferred decreased neuroblastoma risk and two polymorphisms exerted stronger protective effects against neuroblastoma than either one alone.
|
31325764 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These results indicate that the <i>TP53</i> gene rs1042522 allele G may be a potential protective factor against neu</span>roblastoma in Chinese children.
|
30719141 |
2019 |
|
rs6435862
|
|
|
0.030 |
GeneticVariation |
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs11655237
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings add new evidence of the importance of <i>LINC00673</i> rs11655237 C>T to the risk of de</span>veloping neuroblastoma.
|
31005956 |
2019 |
|
rs17489363
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After adjusted gender and age, seven out of eleven SNPs in <i>BARD1</i> were significant associated with the risk of NB, including one SNP in 5'-UTR (rs17489363 G > A), two SNPs in exon (rs2229571 G > C and rs3738888 C > T), and four SNPs in intron (rs3768716 A > G, rs6435862 T > G, rs3768707 C > T and rs17487792 C > T).
|
31258718 |
2019 |
|
rs217727
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we genotyped three SNPs (rs2839698 G>A, rs3024270 C>G, rs217727 G>A) from <i>H19</i> gene in a Chinese population (700 subjects with neuroblastoma and 1516 control subjects) enrolled from six hospitals and examined the effect of individual and combined SNPs on the risk of neuroblastoma.
|
31772668 |
2019 |
|
rs217727
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Odds ratios (ORs) and 95% confidence intervals (CIs) were used to determine the strength of the association of interest.<b>Results</b> Separated and combined analyses revealed no associations of the rs2839698 G>A, rs3024270 C>G or rs217727 G>A polymorphisms and neuroblastoma susceptibility.
|
30890582 |
2019 |